| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel 4-trimethylammonio-butyrates of formula I,where A, R, m and n are as defined in the description and in the claim, as well as pharmaceutically acceptable salts thereof.EFFECT: compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments for therapeutic or preventive treatment of hyperglycemia, glucose tolerance disorders, diabetes and associated pathologies, non-insulin dependent diabetes mellitus, obesity, hypertension, insulin resistance syndrome, metabolic syndrome, hyperlipidemia, hypercholesterolemia, fatty liver disease, atherosclerosis, congestive heart failure and renal failure.13 cl, 1 tbl, 39 ex |
