发明名称 |
NEW USES OF MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE |
摘要 |
The present invention relates to new uses of modified human tumor necrosis factor receptor-1 (TNFRI) polypeptide, and more particularly, to uses thereof for prevention and treatment of dry eye syndrome. The modified TNFRI or modified TNFRI fragment of the present invention has excellent TNFalpha neutralizing activity, and inhibits TNFalpha activity on the ocular surface of the patient to suppress inflammation induction effects related to dry eye. Therefore, the modified TNFRI or modified TNFRI fragment of the present invention exhibits remarkable effects in the prevention and treatment of dry eye syndrome, and thus can be very useful in the prevention and treatment of dry eye syndrome. |
申请公布号 |
WO2013191352(A1) |
申请公布日期 |
2013.12.27 |
申请号 |
WO2013KR00983 |
申请日期 |
2013.02.07 |
申请人 |
HANALL BIOPHARMA CO., LTD. |
发明人 |
KIM, SUNG WUK;PARK, SEUNG KOOK;SONG, YEON JUNG;KIM, EUN SUN;AHN, HYEA KYUNG;JEONG, JAE KAP;LEE, HUNG KEUN |
分类号 |
A61K38/17;A61K38/16;A61K38/18;A61P27/02 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|