| 摘要 |
PROBLEM TO BE SOLVED: To provide new compounds and methods for using in the treatment of cancer.SOLUTION: An oligonucleotide sequence comprising a specific sequence may contain a phosphate backbone modification. The phosphate backbone modification is preferably a phosphorothioate or phosphorodithioate modification. A medicament is administered topically to a mucous membrane or subcutaneously in a dose effective to up-regulate the expression of at least one of cell surface markers CD20, CD23, CD25, CD40 CD54, CD69, CD80 and CD86, or the medicament is administered topically to a mucous membrane or subcutaneously in a dose effective to induce apoptosis or in a dose effective to activate NK-cells. |
