发明名称 |
Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules |
摘要 |
The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. |
申请公布号 |
US2013345402(A1) |
申请公布日期 |
2013.12.26 |
申请号 |
US201313795346 |
申请日期 |
2013.03.12 |
申请人 |
BAYER HEALTHCARE LLC;BAYER HEALTHCARE LLC |
发明人 |
VOGEL JENS HOLGER;GIOVANNINI ROBERTO;KONSTANTINOV KONSTANTIN B.;NGUYEN HUONG MY;WU PAUL |
分类号 |
C07K1/34 |
主分类号 |
C07K1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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