| 摘要 |
Producing functional fusion tissue, comprises: (a) isolating the cells from tissues of human or animal origin, (b) placing and propagating the isolated cells in a different environment, (c) preparing spheroids from the proliferated cells, (d) fusing at least five spheroids, optionally in the presence of at least one additional differentiation-inducer; or (a) isolating the cells from solid tissues of human or animal origin, (b) preparing dedifferentiated cells from isolated cells, (c) preparing spheroids from the dedifferentiated cells, (d) fusing at least five spheroids. Producing functional fusion tissue, comprises: (a) isolating the cells from tissues of human or animal origin, (b) placing and propagating the isolated cells in a different environment, (c) preparing spheroids from the proliferated cells, (d) fusing at least five spheroids, optionally in the presence of at least one additional differentiation-inducer; or (a) isolating the cells from solid tissues of human or animal origin, (b) preparing dedifferentiated cells from isolated cells, (c) preparing spheroids from the dedifferentiated cells, (d) fusing at least five spheroids, optionally in the presence of at least one additional differentiation-inducer. Independent claims are also included for: (1) functional fusion tissue obtained by the above mentioned method; (2) composition, preferably drug, graft comprising functional fusion tissue and optionally further additives and auxiliaries; (3) a test system, preferably a test kit comprising functional fusion tissue and optionally further additives and auxiliaries; and (4) testing the substances to be examined comprising providing functional fusion tissue or test system, contacting with at least one substance to be examined, and determining the effect of examined substance on the functional fusion tissue. ACTIVITY : Antirheumatic; Antiarthritic; Osteopathic. No biological data given. MECHANISM OF ACTION : None given. |
