发明名称 NEW NON-IONIC SURFACTANTS FOR SOLUBILIZING POORLY SOLUBLE MOLECULES
摘要 New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3-(CH2)x-CH-(CH2)y-CO-[-O-R3-]z-O-R1 R2-O (I); wherein for example R1 is methyl, R2 is optionally substituted C14-C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.
申请公布号 EP1615874(B1) 申请公布日期 2013.12.25
申请号 EP20040727166 申请日期 2004.04.13
申请人 ASTRAZENECA AB 发明人 CORSWANT, CHRISTIAN VON;HULT, KARL;SOEDERLIND, ERIK;VIKLUND, FREDRIK
分类号 A61K9/02;A61K9/00;A61K9/20;A61K9/48;A61K47/14;C08G65/332;C12P7/62 主分类号 A61K9/02
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