发明名称 |
COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
摘要 |
The invention features compositions for treating or preventing a neoplasia. More specifically, the invention provides thienotriazolodiazepine compounds for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail). |
申请公布号 |
EP2571503(A4) |
申请公布日期 |
2013.12.25 |
申请号 |
EP20110781422 |
申请日期 |
2011.05.16 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
BRADNER, JAMES, ELLIOTT;QI, JUN |
分类号 |
C07D495/12;A61K31/5517;A61P35/00;A61P35/02;C07D487/04;C07D495/14;C07D519/00 |
主分类号 |
C07D495/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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