CHIMERIC OLIGOMERIC COMPOUNDS AND THEIR USE IN GENE MODULATION
摘要
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.
申请公布号
CA2504720(C)
申请公布日期
2013.12.24
申请号
CA20032504720
申请日期
2003.11.04
申请人
ISIS PHARMACEUTICALS, INC.
发明人
BAKER, BRENDA F.;ELDRUP, ANNE B.;MANOHARAN, MUTHIAH;BHAT, BALKRISHEN;GRIFFEY, RICHARD;SWAYZE, ERIC E.;CROOKE, STANLEY T.