COMBINATION OF BEVACIZUMAB AND 2,2-DIMETHYL-N-((S)-6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL)-N'-(2,2,3,3,3-PENTAFLUORO-PROPYL)-MALONAMIDE FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

摘要

The present invention relates to a combination therapy of 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide, or a pharmaceutically-acceptable salt thereof, and bevacizumab for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example a brain tumor.