摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compounds of general formula (I), whereis a substituted 5-member heteroaryl ring selected from thienyl, thiazolyl, oxazolyl, pyrrolyl, imidazolyl or pyrazolyl, W is selected from a group comprising N and -C=; M is selected from a group comprising -C(O)N(R)OR, -CXCONRRand -C(O)OR, or M is -C-Calkyl-C(O)N(R)OR, whereinis,Rand Rare independently selected from a group comprising -H, C-C-alkyl, C-aryl, and C-C-alkyl-C-aryl; R is selected from a group comprising H, C-Calkyl, halogen, NRR, -ORand Caryl; n is an integer from 0 to 1; L and Y are as indicated in the claim; and to compounds of formula (II), where Lis selected from a group comprising H, - C-Calkyl- Caryl, -C-Calkyl-heteroaryl, where the heteroaryl is pyridyl; -C-Calkyl, Y and M are the same as for compounds of formula (I). The invention also relates to a pharmaceutical composition based on compounds (I) and (II), having inhibiting action on histone deacetylase (HDAC), a method of inhibiting and a method of treating a disease which is sensitive to the HDAC inhibitor.EFFECT: compounds of formula I and II as histone deacetylase inhibitors.18 cl, 18 dwg, 10 tbl, 19 ex |