The present disclosure provides variant Cas endoribonucleases, nucleic acids encoding the variant Cas endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Cas endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
申请公布号
WO2013188638(A2)
申请公布日期
2013.12.19
申请号
WO2013US45602
申请日期
2013.06.13
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;DOUDNA, JENNIFER A.;JINEK, MARTIN;STERNBERG, SAMUEL H.
发明人
DOUDNA, JENNIFER A.;JINEK, MARTIN;STERNBERG, SAMUEL H.