| 摘要 |
<p>Provided is a method for modifying a strand of RNA at the 3' end, said method comprising contacting the strand with a RNA 2'-0-methyltransferase in the presence of a co-factor, under conditions which allow for the transfer by the RNA 2'-0-methyltransferase of a part of the co-factor onto the 3' end of the RNA strand to form a modified RNA strand, wherein the strand of RNA is comprised in a duplex, and wherein the part of the co-factor transferred comprises a reporter group or a functional group.</p> |
