COMPLEXES OF AMPHOTERICIN B WITH POLY (GLUTAMIC ACID)

摘要

Complexes The invention provides aprocess for the preparation of a complex of Amphotericin B with poly(glutamic acid), which comprises the steps of i) mixing Amphotericin B with poly(glutamic acid) in the presence of water to form an aqueous solution of a complex of Amphotericin B with poly(glutamic acid); and ii) heating at least a portion of said solution at a temperature in the range of from 45 to 95°C for a period of time from 1 to 72 hours. Also provided is a complex of Amphotericin B withpoly(glutamic acid), which is characterised by (a) a ratio of the peak heights of the UV absorbances of the complex in the regions of 315 and 406 nm of the complex of least 4.5, and (b) a shift of the UV peak of the complex away from 328 nm which is decreased by at least 1 nm compared with the peak shift of the unheated complex.