发明名称 |
ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
Described herein are antimicrobial compounds identified via a high-throughput inhibitor screen of the in vitro activity of MipZ, which is an ATPase that regulates division site placement in Caulobacter crescentus. The compounds and their analogs are active against bacterial membranes and thus represent a novel class of antimicrobial compounds. The antimicrobial compounds are effective against both actively growing bacterial cells as well as bacterial cells in the stationary phase. The antimicrobial compounds are also effective against bacteria in biofilms. |
申请公布号 |
US2013331424(A1) |
申请公布日期 |
2013.12.12 |
申请号 |
US201313913912 |
申请日期 |
2013.06.10 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
WEIBEL DOUGLAS BENJAMIN;EUN YE JIN;FOSS MARIE HAZEL;HURLEY KATHERINE ANN |
分类号 |
A61K31/403;A61K31/4045 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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