PERIPHERAL KAPPA RECEPTOR AGONISTS FOR REDUCING PAIN AND INFLAMMATION
摘要
A method of treating of a mammalian subject suffering from an inflammatory disease or condition by administering a peripherally-restricted kappa opioid receptor agonist for reducing the inflammation is provided. The peripherally-restricted kappa opioid receptor agonist can include a peptide and the peptide can include D-amino acids. Administration of peripherally- restricted kappa opioid receptor agonists results in lowering of serum levels of pro-inflammatory cytokines and elevation of levels of anti-inflammatory cytokines.
申请公布号
WO2013184794(A2)
申请公布日期
2013.12.12
申请号
WO2013US44302
申请日期
2013.06.05
申请人
CARA THERAPEUTICS, INC.
发明人
CHALMERS, DEREK, T.;JONES, JAMES, B.;SPENCER, ROBERT, H.