发明名称 |
Recombinant microorganisms and uses therefor |
摘要 |
Bacteria are genetically engineered to produce 3-hydroxypropionate (3-HP). The bacteria are carboxydotrophic acetogens. The bacteria produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A malonyl-coA reductase from a bacterium that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced The production of 3-HP can be improved by overproduction of acetyl-CoA carboxylase or by overproduction of biotin. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient. |
申请公布号 |
US2013323806(A1) |
申请公布日期 |
2013.12.05 |
申请号 |
US201313905143 |
申请日期 |
2013.05.30 |
申请人 |
LANZATECH NEW ZEALAND LIMITED |
发明人 |
KOEPKE MICHAEL;CHEN WENDY YITING |
分类号 |
C12P7/52;C12R1/145 |
主分类号 |
C12P7/52 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|