发明名称 |
DOUBLE STRANDED OLIGONUCLEOTIDE COMPOUNDS COMPRISING POSITIONAL MODIFICATIONS |
摘要 |
Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof. |
申请公布号 |
US2013324591(A1) |
申请公布日期 |
2013.12.05 |
申请号 |
US201113991610 |
申请日期 |
2011.12.06 |
申请人 |
AVKIN-NACHUM SHARON;FEINSTEIN ELENA;BEIGELMAN LEONID;QUARK PHARMACEUTICALS, INC. |
发明人 |
AVKIN-NACHUM SHARON;FEINSTEIN ELENA;BEIGELMAN LEONID |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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