MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF

摘要

Provided are modified factor IX polypeptides and uses thereof. The modified FIX polypeptides include FIXa and different forms of FIX. Among the modified FIX polypeptides provided in the present invention, polypeptides with modified activities and typically modified clot-promoting activities such as increased clot-promoting activities exist. Therefore, the modified polypeptides are medicines. [Reference numerals] (AA) Intrinsic pathway;(BB) Zymogen;(CC) Protease;(DD) Extrinsic pathway;(EE) General pathway;(FF) Prothrombin;(GG) Thrombin;(HH) Fibrinogen;(HMWK) HMW kallikrein;(II) Fibrin;(JJ) Fibrin (crosslinked);(K) Kallikrein;(KK) Coagulation cascade;(PK) Prekallikrein;(TF) Tissue factor