TETRAZINE-TRANS-CYCLOOCTENE LIGATION FOR THE RAPID CONSTRUCTION OF RADIONUCLIDE LABELED PROBES
摘要
<p>A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.</p>
申请公布号
EP2595967(A4)
申请公布日期
2013.12.04
申请号
EP20110810394
申请日期
2011.07.21
申请人
UNIVERSITY OF DELAWARE;UNIVERSITY OF SOUTHERN CALIFORNIA
发明人
FOX, JOSEPH M.;HASSINK, MATTHEW;BLACKMAN, MELISSA;LI, ZIBO;CONTI, PETER S.;SELVARAJ, RAMAJEYAM