发明名称 |
POSACONAZOLE INTRAVENOUS SOLUTION FORMULATIONS STABILIZED BY SUBSTITUTED BETA-CYCLODEXTRIN |
摘要 |
The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified &bgr;-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties. |
申请公布号 |
EP2588116(A4) |
申请公布日期 |
2013.12.04 |
申请号 |
EP20110804061 |
申请日期 |
2011.06.24 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
HEIMBECHER, SUSAN, K.;MONTEITH, DAVID |
分类号 |
A61K31/715;A61K31/497 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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