ANTIBODIES SELECTIVE FOR CELLS PRESENTING EGFR AT HIGH DENSITY
摘要
<p>Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.</p>
申请公布号
EP2668209(A1)
申请公布日期
2013.12.04
申请号
EP20120738907
申请日期
2012.01.20
申请人
YM BIOSCIENCES INC.;NATIONAL RESEARCH COUNCIL OF CANADA
发明人
TIKHOMIROV, ILIA ALEXANDRE;JARAMILLO, MARIA L.;O'CONNOR-MCCOURT, MAUREEN D.;SULEA, TRAIAN;GILBERT, RENALD;GAILLET, BRUNO;BAARDSNES, JASON;BANVILLE, MYRIAM;GROTHE, SUZANNE