发明名称 |
Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
摘要 |
This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
申请公布号 |
US8598321(B2) |
申请公布日期 |
2013.12.03 |
申请号 |
US20080528601 |
申请日期 |
2008.03.21 |
申请人 |
MARKS JAMES D.;GEREN ISIN N.;LOU JIANLONG;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MARKS JAMES D.;GEREN ISIN N.;LOU JIANLONG |
分类号 |
A61K38/00;A01N37/18;A61K38/16;A61K39/385;A61K39/40;A61K39/42;C07K16/00;C12P21/08;G01N33/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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