| 摘要 |
596669 Disclosed herein is a pyrrolo[3,2-b]pyrrole compound of formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of a cancer, such as sarcomas, bladder cancers, ovarian cancers, breast cancers, brain cancers, pancreatic cancers, colon cancers, blood cancers, skin cancers, lung cancers and bone cancers. Embodiments of the compound include the following: N,N'-bis-{ 2-[4-[3,3-dimethyl-2-(2-methylaminopropionylamino)-butyryl]-3-(4-fluoro-phenylcarbamoyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-2-oxo-ethyI} -oxalamide, and 4-[3,3-dimethyl-2-(2-methylamino-propionvlamino)-butyryl]-1-methanesulfonyl-octahydro-pyrrolo[3,2-b]pyrrole-3-carboxylic acid guinolin-2-ylamide. |
