发明名称 |
Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents |
摘要 |
A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone. |
申请公布号 |
AU2012250451(A1) |
申请公布日期 |
2013.11.28 |
申请号 |
AU20120250451 |
申请日期 |
2012.05.02 |
申请人 |
BROCK UNIVERSITY |
发明人 |
HUDLICKY, TOMAS;WERNER, LUKAS;WERNEROVA, MARTINA;ENDOMA-ARIAS, MARY ANN;MACHARA, ALES |
分类号 |
C07D498/22;C07D489/08 |
主分类号 |
C07D498/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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