发明名称 |
NEW CATHEPSIN S PROTEASE INHIBITORS, USEFUL IN THE TREATMENT OF E.G. AUTOIMMUNE DISORDERS, ALLERGY AND CHRONIC PAIN CONDITIONS |
摘要 |
There is provided a process for the preparation of a compound of formula III, comprising the step of oxidising the compound of formula 2b wherein n is 2; R 2a and R 2b are independently H or F; R 3 is 1-methylcyclopentylmethyl or 1-fluorocyclopentylmethyl; R 3' is CH 3 or F; R 4 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 3 -C 6 cycloalkyl, wherein C 3 -C 6 cycloalkyl is optionally substituted with methyl, CF 3 or one or two fluoro. Compounds and processes used in the preparation of a compound of formula III are also provided. |
申请公布号 |
EP2582660(A4) |
申请公布日期 |
2013.11.27 |
申请号 |
EP20110795278 |
申请日期 |
2011.06.16 |
申请人 |
MEDIVIR UK LTD |
发明人 |
AYESA, SUSANA;GRABOWSKA,URSZULA;HEWITT, ELLEN;JOENSSON, DANIEL;KLASSON, BJOERN;KAHNBERG, PIA;LUNDGREN, STINA;TEJBRANT, JAN;WIKTELIUS, DANIEL |
分类号 |
C07C237/14;A61K31/16;A61P11/00;A61P37/00;C07D233/58 |
主分类号 |
C07C237/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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