摘要 |
The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use. |
申请人 |
BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
DITTMER, FRANK;BUCHMUELLER, ANJA;GERDES, CHRISTOPH;TERSTEEGEN, ADRIAN;GNOTH, MARK, JEAN;LINDEN, LARS;HARRENGA, AXEL;GRUDZINSKA-GOEBEL, JOANNA;JESKE, MARIO;SCHAEFER, MARTINA;BIRKENFELD, JOERG;PAULSEN, HOLGER;FINNERN, RICARDA;MAYER-BARTSCHMID, ANKE;EICKER, ANDREA;GREVEN, SIMONE;STEINIG, SUSANNE |