发明名称 |
Method for screening anti-ligand libraries for identifying anti-ligands specific for differentially and infrequently expressed ligands |
摘要 |
The present invention relates to screening methods and, in particular, to methods of screening anti-ligands libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
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申请公布号 |
US8592347(B2) |
申请公布日期 |
2013.11.26 |
申请号 |
US20030526695 |
申请日期 |
2003.09.03 |
申请人 |
FRENDEUS BJOERN;BIOINVENT INTERNATIOAL AB |
发明人 |
FRENDEUS BJOERN |
分类号 |
C40B20/02;C40B20/04;C40B20/06;C40B20/08;C40B30/04;G01N33/68 |
主分类号 |
C40B20/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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