Allergen variants

摘要

The present invention relates to a method for producing a hypoallergenic variant of an allergenic polypeptide having one or more loop regions comprising the step of modifying at least one loop region within the allergenic polypeptide by dividing said at least one loop region into at least two fragments, each of said fragments comprising at least 4 amino acid residues and rejoining said at least two fragments in a different order than in said allergenic polypeptide.