DETECTION METHOD OF SENSITIVE GENES FOR HIGH-DOSE-RATE RADIATION AND GENES DETECTED BY THIS METHOD

摘要

The present invention relates to a method for detecting a gene which is sensitive to high-dose ionizing radiation and a gene detected thereby. More specifically, the present invention provides a method for detecting a gene which is searched in a cancer-induced individual, is verified in a normal individual, and is sensitive to high-dose ionizing radiation by irradiating a cancer-induced ARK/J mouse and a normal ICR mouse with high-dose ionizing radiation and collecting thymuses from the mice; performing microarray of the thymuses; classifying fatty acid metabolism-related genes; and amplifying the genes and measuring expression levels of the genes. The present invention enables accurately detecting a gene which specifically responds to radiation by preventing intervention of confounding variables. [Reference numerals] (AA) High level radiation (0.8 Gy/min);(BB) Thymus cell;(CC) Nucleus;(DD) ��ong chain fatty acid;(EE) Cytoplasm;(FF) ��itochondria synthesis;(GG) ��aturated fatty acid;(HH) ��ipid toxicity;(II) Thymus cancer deterioration