MINICIRCLE EXPRESSING ANTI-IL-6R ANTIBODY FOR PREVENTING AND TREATING AUTOIMMUNE DISEASE

摘要

The present invention relates to a pharmaceutical composition containing a minicircle vector which expresses anti-IL-6R for treating autoimmune diseases. The pharmaceutical composition of the present invention contains (a) a gene expression cassette containing a promoter, a gene encoding anti-IL-6R monoclonal antibodies, and a transcription terminator; (b) a site-specific recombinant region located at the outside of the gene expression cassette; and (c) a non-viral vector which does not contain a replication origin and a selection marker gene as active ingredients.