发明名称 |
COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF |
摘要 |
Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed. Compounds of the invention include N-(3-(trifluoromethyl)phenyl )-2-methyl-1-(3-morpholinopropyl )-5-phenyl-1 H-pyrrole-3-carboxamide, as well as other 2-phenyl-pyrrole carboxamide derivates and indole carboxamide derivatives. |
申请公布号 |
WO2013169396(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
WO2013US32623 |
申请日期 |
2013.03.15 |
申请人 |
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
KRIZAJ, DAVID;PRESTWICH, GLENN D.;BARABAS, PETER;XU, YONG;RYSKAMP, DANIEL |
分类号 |
C07D207/30;C07D207/32 |
主分类号 |
C07D207/30 |
代理机构 |
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代理人 |
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地址 |
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