SOLUBILITY ENHANCED COMPOSITIONS

摘要

Solubility-enhanced compositions comprising synergistic combinations of cellulosic polymers, polyvinyl acetate phthalate and poorly soluble drugs are provided. The poorly soluble drugs in the solubility-enhanced compositions have apparent aqueous solubilities at least 1.5 times higher than the equilibrium solubilities of the crystalline forms of the drugs. Orally-ingestible dosage forms comprising these solubility-enhanced compositions are also disclosed.