| 摘要 |
<p>The present invention describes the method for producing the dichloromethane fraction and subfractions of Eleutherine plicata, commonly known as "marupazinho, maruparí, palmeirinha, coquinho, marupaí, marupaú, marupá-piranga, lírio-folha-de-palmeira". The invention further includes the preparation of pharmaceutical compositions that contain the dichloromethane fraction and/or naphthoquinone, as well as the use thereof for the treatment of malaria. The extract and fractions described were tested and showed antiplasmodium activity, in particular against chloroquine-resistant Plasmodium falciparum (W2).</p> |
| 申请人 |
UNIVERSIDADE FEDERAL DO PARA - UFPA;UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG;MUSEU PARAENSE EMILIO GOELDI;INSTITUTO EVANDRO CHAGAS;SECRETARIA EXECUTIVA DE SAUDE PUBLICA DO ESTADO DO PARA |
发明人 |
DOLABELA, MARIA FANI;MARTINS, MICHEL T.;BRANDAO, DAYSE LUCIA DO NASCIMENTO;BORGES, EDINILZA DA SILVA;PERCARIO, SANDRO;MARINHO, ANDREY MOACIR DO R.;SILVA, THIAGO L. DA;VILHENA, THYAGO DA COSTA;VASCONCELOS, FLAVIO DE;MOTA, EDUARDO F.;SILVA, ADRIANA VEIGA DA CONCEICAO;OLIVEIRA, ALAIDE BRAGA DE;BRANDAO, GERALDO CELIO;PAULA, RENATA CRISTINA DE;NASCIMENTO, MARIA FERNANDA ALVES DO;POVOA, MARINETE MARINS;COELHO-FERREIRA, MARLIA REGINA;BUSMAN, DAMARIS |
