发明名称 |
Detection and treatment of schizophrenia |
摘要 |
The present invention relates to a method for diagnosing schizophrenia comprising measuring at least one parameter in a subject, the parameter being selected from the group consisting of (1) a genetic abnormality of glyoxalase I gene, (2) the expression level or activity of glyoxalase I in a biological sample, (3) the amount of a carbonyl-modified protein that is a protein modified with the carbonyl-compound, preferably pentosidine, in a biological sample, and (4) the amount of pyridoxal in a biological sample. The present further relates to a primer, a probe and a reagent for use in said method, as well as an AGE-reader and its use for measuring the amount of carbonyl-modified proteins. |
申请公布号 |
EP2662453(A2) |
申请公布日期 |
2013.11.13 |
申请号 |
EP20130003496 |
申请日期 |
2008.07.31 |
申请人 |
TOKAI UNIVERSITY EDUCATIONAL SYSTEM;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE;RENASCIENCE CO., LTD.;MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD. |
发明人 |
ITOKAWA, MASANARI;MIYATA, TOSHIO;ARAI, MAKOTO |
分类号 |
C12Q1/68;A61K31/415;A61K31/4152;A61K31/437;A61K31/4415;A61K31/4439;A61K45/00;A61P25/18;C12N15/09;G01N30/88;G01N33/15 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|