发明名称 |
Antibody producing non-human mammals |
摘要 |
<p>The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.</p> |
申请公布号 |
EP2147594(B1) |
申请公布日期 |
2013.11.13 |
申请号 |
EP20090075279 |
申请日期 |
2009.06.29 |
申请人 |
MERUS B.V. |
发明人 |
HOUTZAGER, ERWIN;PINTO, RUI DANIEL;LOGTENBERG, TON;THROSBY, MARK |
分类号 |
A01K67/027;C07K16/00;C12N5/10;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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