摘要 |
The invention relates to an antibody, or antigen-binding fragment thereof, that binds specifically to a sclerostin polypeptide. The antibody or antigen-binding fragment is useful for increasing bone mineral content and/or bone mineral density in a warm-blooded animal or human, for example in the treatment of conditions such as osteopenia, osteoporosis, a fracture, achondroplasia, cleidrocranial dysostosis, echondromatosis, fibrous dysplasia, Gaucher's Disease, hypophoshatemic rickets, Marfan's syndrome, multiple hereditary exotoses, neurofibromatosis, osteogenesis inperfecta, osteopetrosis, osteopoikilosis, sclerotic lesions, peridontal disease, pseudoarthosis and pyogenic osteolmyelitis.
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申请人 |
CELLTECH R & D, INC.;UCB MANUFACTURING, INC. |
发明人 |
BRUNKOW, MARY E.;GALAS, DAVID J.;KOVACEVICH, BRIAN;MULLIGAN, JOHN T.;PAEPER, BRYAN W.;VAN NESS, JEFFREY;WINKLER, DAVID G. |