| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method for preparing a dry water-dispersed pharmaceutical composition. The method consists in dispersing an active substance in a fatty acid ester and polyoxyethylene 32 melted below 80°C, and spraying the hot dispersion onto the grain excipient in a fluid bed. Once the powder cooled down, inert excipients introducible through the digestive tract are added. The invention also refers to an oral pharmaceutical composition containing the mixture prepared by the above method.EFFECT: invention aims at solving the problem of solubilisation and intestinal absorption of the active substances which are poorly water-soluble or water-insoluble, and cannot be salinated in the gastric juice.16 cl, 4 dwg, 3 ex |
