发明名称 |
NON-THIOPURINE METHYLTRANSFERASE RELATED EFFECTS IN 6-MERCAPTOPURINE THERAPY |
摘要 |
The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease, in particular, the present invention provides methods for predicting a patient's risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient at a polymorphic site in at least one gene selected from the group consisting of a xanthine dehydrogenase (XDH) gene, molybdenum cofactor sulfurase (MOCOS) gene, and aldehyde oxidase (AOX) gene. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a 6-mercaptopurine drug by determining whether the patient should be given an alternative drug based on the presence or absence of a polymorphism in at least one of the XDH, MOCOS, and AOX genes. |
申请公布号 |
WO2013164757(A1) |
申请公布日期 |
2013.11.07 |
申请号 |
WO2013IB53390 |
申请日期 |
2013.04.29 |
申请人 |
GUY'S AND ST. THOMAS' NHS FOUNDATION TRUST |
发明人 |
SANDERSON, JEREMY D.;MARINAKI, ANTHONY M.;SMITH, MELISSA A.;BLAKER, PAUL A. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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