发明名称 MODIFIED PROKARYOTIC UBIQUITIN-LIKE PROTEIN AND METHODS OF USE THEREOF
摘要 <p>Methods for making and using substrates of deamidase of prokaryotic ubiquitin-like protein (Dop) are described herein. More particularly, modified prokaryotic ubiquitin-like protein (Pup) and functional fragments thereof that serve as exemplary Dop substrates are described and encompassed herein. Screening methods to identify modulators of Dop and Pup activity and use of modulators identified thereby are also described. Methods of using modulators that are identified as inhibitors of Dop and Pup activity for treating diseases/conditions associated with Mycobacterium tuberculosis (Mtb) infection, such as tuberculosis and leprosy, are also envisioned.</p>
申请公布号 WO2013166234(A1) 申请公布日期 2013.11.07
申请号 WO2013US39190 申请日期 2013.05.02
申请人 NEW YORK UNIVERSITY 发明人 MERKX, NICOLAAS, SEBASTIAAN, MICHEL;OVAA, HUIB;DARWIN, KATERINA, HERAN
分类号 C07K14/195;G01N33/53 主分类号 C07K14/195
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