发明名称 |
NOVEL USE OF TANSHINONEIIA FOR INHIBITION OF FUNCTIONAL PLASTICITY OF REGULATORY T CELLS |
摘要 |
The present invention relates to a novel use of tanshinone IIA which suppresses differentiation plasticity of regulatory T cells (Treg) and, specifically, to a composition containing tanshinone IIA as an active ingredient for suppressing differentiation of Treg cell into Th17 cells; a composition containing tanshinone IIA and Treg cells as active ingredients for preventing or treating immune diseases; and a method for producing Treg cells using tanshinone IIA, in which immunosuppressive function is maintained. According to the present invention, tanshinone IIA effectively maintains and enhances the function of Treg cells by suppressing differentiation plasticity of Treg cells into Th17 cells, thereby blocking differentiation of Treg cells into Th17 cells under a pathological condition when being alternately used with Treg cells and providing a therapeutic agent for effectively treating immune diseases. |
申请公布号 |
KR20130122446(A) |
申请公布日期 |
2013.11.07 |
申请号 |
KR20120045791 |
申请日期 |
2012.04.30 |
申请人 |
CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION |
发明人 |
YANG, CHUL WOO;CHO, MI LA;LEE, SEON YEONG;MUN, YEONG MI;HER, YANG MI;SON, HYE JIN;RYU, JUN GEOL |
分类号 |
C12N5/0783;A61K35/12;C07D307/79;C12N5/02 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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