发明名称 |
DETECTING COMPLEMENT ACTIVATION |
摘要 |
Methods of detecting complement activation including steps of detecting in a sample from a subject a level of iC3b wherein the detecting involves specific interaction between the iC3b and a non-cross-reactive antibody thereto, comparing the detected level with a reference level, which reference level is within a range of about 10 ng/ml to about 5,000 ng/ml, wherein determination that the detected level is above the reference level indicates that the subject is suffering from or susceptible to undesirable and/or pathologic complement activation, and administering treatment to treat undesired complement activation if the detected level is above the reference level. Other methods of detecting complement activation with or without measuring iC3b are also provided. |
申请公布号 |
CA2871910(A1) |
申请公布日期 |
2013.11.07 |
申请号 |
CA20132871910 |
申请日期 |
2013.04.30 |
申请人 |
KYPHA, INC. |
发明人 |
OLSON, PAUL;MOSS, DONALD W.;STATEN, NICK |
分类号 |
G01N33/558;A61K39/395;A61P9/00;A61P13/12;A61P25/00;A61P27/02;A61P29/00;A61P31/00;G01N33/53;G01N33/68 |
主分类号 |
G01N33/558 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|