ANTI-INFLAMMATORY AGENT CONTAINING HELIANTHUS TUBEROSUS AERIAL PART EXTRACTS

摘要

Provided is a pharmaceutical composition containing an aerial part extract of Helianthus tuberosus for preventing and treating inflammation, which is safely used without side effects and toxicity using the aerial part extract of Helianthus tuberosus, a natural product which is easy to obtain in Korea. More specifically, as a result of testing inflammation effect of a composition which is prepared by fractioning and extracting a concentrate using a solvent, which is obtained from an aerial part of Helianthus tuberosus by hot water extraction, the composition is identified to suppress the generation of TNF-alpha, IL-6, and IL-1 beta which are inflammatory mediators and increase the biosynthesis of TNF-alpha, IL-6, and IL-1 beta in macrophage primary cells which are activated by LPS. Therefore, the composition suppresses NO generation in the aerial part extract of Helianthus tuberosus and has anti-inflammation effect.