The present process provides an improved method for the preparation of 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydrox-ymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one of the formula (IV) which is a potent inhibitor of Hepatitis C Virus (HCV) NS5B polymerase.
申请公布号
DK2084174(T3)
申请公布日期
2013.11.04
申请号
DK20070839369T
申请日期
2007.10.05
申请人
GILEAD PHARMASSET LLC;F. HOFFMANN-LA ROCHE AG
发明人
AXT, STEVEN D.;SARMA, KESHAB;VITALE, JUSTIN;ZHU, JIANG;ROSS, BRUCE;RACHAKONDA, SUGUNA;JIN, QINGWU;CHUN, BYOUNG-KWON
