发明名称 METHODS FOR ADMINISTRATION OF CITICOLINE IN STROKE TREATMENT
摘要 The present invention provides administration methods for CDPC for treating stroke. CDPC was delivered via ECS at a concentration of 40 mmol/L-60 mmol/L. In a specific embodiment of the present invention, the concentration of CDPC administered is 50 mmol/L, CDPC is delivered at one time, the flow rate of administration is 0.2 muL/min, the volume of CDPC is 1.33 muL/mL of brain tissue, and the CDPC is administered in the caudate nucleus. The method can decrease the concentration of CDPC entering the brain and further decrease the dosage while improving efficacy. Thus, the result is improved and the probability of adverse effects due to the drug is reduced.
申请公布号 US2013288995(A1) 申请公布日期 2013.10.31
申请号 US201313923512 申请日期 2013.06.21
申请人 PEKING UNIVERSITY THIRD HOSPITAL 发明人 HAN HONGBIN
分类号 A61K31/7068 主分类号 A61K31/7068
代理机构 代理人
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