| 摘要 |
<p>A compound of the general formula: (I) wherein the symbols are as defined in the description, or a prodrug or salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urologic diseases (symptoms associated with prostate-gland enlargement or neuropathic bladder, bone tomors of the spine, disk herniation, spinal canal stenosis, symptoms attributed to diabetes, lower urinary tract infections (e.g., obstruction of lower urinary tract), inflammation of lower urinary tract and polyuria), cancer-associated diseases (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi’s sarcoma, leukemia and wet metastasis of cancer), proliferative diseases (diseases accompanied by abnormal angiogenesis, blocked artery and lung fibrosis), inflammation/immune diseases (psoriasis, nephropathy, hepatisis and pneumonia), diseases caused by secretion disorder (Sjogren’s syndrome) or brain-associated diseases (brain block, cerebral hemorrhage and cerebral or peripheral nerve disorder).</p> |
