发明名称 |
RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ |
摘要 |
PROBLEM TO BE SOLVED: To provide recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin.SOLUTION: A method for synthesizing influenza virus-like particles (VLPs) in a plant or in a portion of a plant is provided. The method involves expression of influenza HA in a plant, and purification thereof by size exclusion chromatography. The invention also relates to VLPs comprising influenza HA protein and plant lipids. The invention is further directed to a nucleic acid encoding the influenza HA protein as well as vectors. The VLPs may be used for formulating influenza vaccines or may be used to enrich existing vaccines.SELECTED DRAWING: Figure 2A |
申请公布号 |
ZA201005917(B) |
申请公布日期 |
2013.10.30 |
申请号 |
ZA20100005917 |
申请日期 |
2010.08.19 |
申请人 |
MEDICAGO INC |
发明人 |
D'AOUST MARC-ANDRE;COUTURE MANON;ORS FREDERIC;TREPANIER SONIA;LAVOIE PIERRE-OLIVIER;DARGIS MICHELE;VEZINA LOUIS-PHILIPPE;LANDRY NATHALIE |
分类号 |
C12N;A01H;A61K;A61P;C07K |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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