发明名称 |
HUMAN IL-1 BETA ANTAGONISTS |
摘要 |
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.
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申请公布号 |
CA2509136(C) |
申请公布日期 |
2013.10.29 |
申请号 |
CA20042509136 |
申请日期 |
2004.01.21 |
申请人 |
APPLIED MOLECULAR EVOLUTION, INC. |
发明人 |
DICKINSON, CRAIG DUANE;VASSEROT, ALAIN PHILIPPE;WATKINS, JEFFRY DEAN;LU, JIRONG |
分类号 |
C12N15/13;A61K39/395;A61P19/02;A61P25/00;A61P37/00;C07K16/24 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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