| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to a piperazine compound presented by formula, wherein Rrepresents Calkyl; Rrepresents hydroxy, Calkyl which can contain a substitute specified in saturated or unsaturated 5-6 member heterocycle with 1-3 heteroatoms specified in oxygen and nitrogen, -(C=O)-N(R)(R) or -(C=O)-OR; Rand Rmay be identical or different, and each represents hydrogen or Calkyl which can contain a substitute specified in saturated or unsaturated 5-6 member heterocycle with 1-3 heteroatoms specified in oxygen and nitrogen, or Rand Rbound through a nitrogen atom whereto Rand Rare attached, can form a saturated heterocyclic group specified in 5-6 member heterocycle with 1-3 heteroatoms specified in oxygen and nitrogen; Rrepresents hydrogen or Calkyl; and n represents 1 or 2; or a salt thereof. Also, the invention refers to a pharmaceutical compositions and an agent exhibiting prostaglandin-D-synthase activity and based on the compound of formula I, as well as to a method of preventing and treating a disease wherein prostaglandin D2 is involved.EFFECT: there are prepared and described new compounds which may be effective in treating the diseases wherein prostaglandin D2 is involved.11 cl, 19 ex, 4 tbl |
