PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS

摘要

597551 Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification; a pharmaceutical composition comprising said compound; and the use of said compound in the treatment of a disease or condition mediated by CDK9, such as cancer, cardiac hypotrophy, HIV, and inflammatory diseases. Embodiments of the compound include the following: 3,5'-dichloro-N2'-(trans-4-(((R)-2,2-dimethy-1-1,3-dioxolan-4-yl)methyl)aminocyclohexyl)-N6-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine, and trans-4-(5-chloro-4-(6-((tetrahydro-2H-pyran-3-yl)methyl)aminopyrazin-2-yl)pyridin-2-yl-amino)cyclohexanol.