| 摘要 |
Abstract - 602556 Disclosed are cyclohexyl amine derivatives as represented by the general formula (I), or pharmaceutically acceptable salts or N-oxides or solvates or deuterated derivatives thereof, wherein: both X and Y represents a hydrogen atom or, X together with Y form the group -CH=CH-, -CH2-O- or -S-, wherein in the case of -CH2-O- the methylene group is bound to the carbon atom in the amido substituent holding X and the oxygen atom is bound to the carbon atom in the phenyl ring holding Y; R1 and R2 independently represent a hydrogen atom or an alkyl group; R3 represents a C(Ra)(Rb)(Rc) group, a 9-(Ra)-fluoren-9-yl group or a 9-(Ra)-xanthen-9-yl group; and wherein the remaining substituents are as defined herein. Representative compounds include formic acid - trans-4-[(9-{ [(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino} nonyl)(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate, trans-4-[{ 2-[({ [2-chloro-4-({ [(2R)-2-hydroxy-2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino} methyl)-5-methoxyphenyl]amino} carbonyl)oxy]-ethyl} (methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate and trans-4-[{ 2-[({ [2-chloro-4-({ [(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino} methyl)-5-methoxyphenyl]amino} carbonyl)oxy]ethyl} -(methyl) amino]cyclohexyl (2S)-cyclopentyl(hydroxy)2-thienylacetate. Also disclosed is a pharmaceutical composition comprising a compound as defined above in association with a pharmaceutically acceptable diluent or carrier, for the treatment of a pathological condition or disease pulmonary diseases, pre-labor, glaucoma, neurological disorders, cardiac disorders, inflammation and gastrointestinal disorders, asthma and/or chronic obstructive pulmonary disease. |
